Zhou Yu tonyzhou at cdisn.cd.sc.cn
Mon Jan 6 22:30:20 EST 1997

I am immunizing rabbits with Blood Factor VIII/vWF(Mw=1000-12000kd) in 
intrasplenic way to shorten the period. But I am afriend the dose (1mg 
protein in buffer) may be too high. Will it establize a state of 
unresponsiveness or immunological tolerance?
Can someone tell me the proper immunization dose? Thank you for the help!

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