Same function-diverse structures
ogandril at cri.ens-lyon.fr
Tue Jan 14 05:36:12 EST 1997
I don't knwo whether it has been discussed somewhere but you can try the
transferrin receptor in mammals and in bacteria. Both do bind
transferrin but are absolutely not related in their sequence. As far as
the bacterial sequence is concerned, you can start with
Variable sequences in a mosaic-like domain of meningococcal tbp2
encode immunoreactive epitopes.
FEMS Microbiol Lett 132, 277-283 (1995) 
I don't have no reference to mammalian sequences at hand but you can
medline those easily. Hope this helps.
FABIAN MOEBIUS wrote:
> Dear netters,
> I am in search for example of proteins which have the same function
> e.g. catalyze identical biochemical reactions but are structurally
> UNRELATED with respect to their primary structure AND/OR topology. My
> interest is focussed on membrane proteins. I am also interested in
> the evolutional aspect involved.
> If you are aware of such examples or literature discussing the
> problem please let me know. You may prefer
> to send this to my personal Email because this supposingly is not
> interesting for everybody in the newsgroup.
> Dr. Fabian F. MOEBIUS
> Institut fuer Biochemische Pharmakologie
> Peter Mayr Str. 1
> 6020 Innsbruck
> TEL ++43-512-507-3155
> FAX ++43-512-588627
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