Human Ig gene-diversity
andrei.popov at SPAM.bbsrc.ac.uk
Thu Jul 24 11:24:19 EST 1997
Troels Wind wrote:
> Hi all,
> I'm currently trying to collect some data on the HUMAN Ig-loci and now
> I turn to you for some easy obtainable info. ^^^^^
> The problem is that I cant find any refs that states the accurate number
> of various Ig gene-segments in humans, only those in mouse.
if it is _easy_ obtainable info (which indeed IS the case) why bother
So far I've
> got the following:
> #VH fragments: 51 (something tells me that the true number is 49...?)
look for papers by Ian Tomlinson and Graham Cook
Immunol Today etc.
Also I.Tomlinson maintains a database of human V genes
at the LMB MRC Cambridge UK - check WWW
> #D fragments: ?
S. Williams 1997 JMB
> #JH fragments: ?
T. Rabbits et al.
> #VL(kappa) fragments: ?
H. Zachau et al.
> #VL(lambda) fragments: 37
fewer, around 30-31 functional
Williams, Frippiat, Ignatovitch
> #JL(kappa) fragments: 5
> #JL(lambda) fragments: ?
7, Vasicek and Leder
> Evidently this is a very incomplete list, can you help me out?
> Thanks in advance!
> Troels Wind
> Aarhus University
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