Detection of DNA adducts

Michael Clayton clayton- at IX.NETCOM.COM
Mon Nov 10 15:51:19 EST 1997

I am currently trying to quantify 8-hydroxyguanine in human tissue,
using HPLC-ECD.  My method for DNA extraction and hydrolysis seems to
give me very "dirty" samples.  I am wondering if anyone else is studying
this and running into the same problems.  Any advice or comments would
be greatly appreciated.

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