which amino acid mimicking phosphotyrosine?

hammer at liai.org hammer at liai.org
Mon Oct 6 10:12:15 EST 1997


Hi netters!

I would like to make a constitutive active mutant of a protein which 
is activared by tyrosine phosphorylation.

I am thinking of substituting the the tyrosine residue by aspartic 
acid. Is aspartic acid mimicking phosphotyrosine?

Are there any references?

Any hint will be appreciated,

thanks,

Stephan



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