Inclusion bodies? yes, but my protein isn't in them...precedent?
zinc at genetics.utah.edu
Mon Oct 20 19:23:50 EST 1997
davesmith at bioch.tamu.edu writes:
> Just discovered that our integral membrane protein induces inclusion
> bodies when overexpressed. Surprisingly, however, our protein goes to
> the membrane. There is little if any in the inclusion bodies!
> Care to hazard a model??
sure, why not? i bet your membrane protein is simply presenting a nice
hydrophobic surface that either prevents other proteins from folding
or that actively unfolds already folding proteins. perhaps you have an
'anti-chaperonin' on your hands.
"There is only one aim in life and that is to live it."
Karl Shapiro,(1959) from an essay on Henry Miller's Tropic of Cancer
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