Inclusion bodies? yes, but my protein isn't in them...precedent?

[pjf]

davesmith at bioch.tamu.edu writes:

> Just discovered that our integral membrane protein induces inclusion
> bodies when overexpressed.  Surprisingly, however, our protein goes to
> the membrane.  There is little if any in the inclusion bodies!
> 
> Care to hazard a model??

sure, why not? i bet your membrane protein is simply presenting a nice 
hydrophobic surface that either prevents other proteins from folding
or that actively unfolds already folding proteins. perhaps you have an 
'anti-chaperonin' on your hands.

-pjf

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