start codons other than ATG
Koen De Smet
k.desmet at nospam.ic.ac.uk
Mon Sep 1 10:35:55 EST 1997
Amalia Gomez Serrano wrote:
> Is the occurrence of other start codons different from ATG, i.e. GTG,TTG
> or CTG linked to any specific factor?
> is it species, genra- linked?
> has anybody any knowledge on this subject, or any reference i could look
> Thanks in advance
A GTG start codon is very common in mycobacteria, but as far as I know,
nodbody knows why certain genes in these organisms have ATG, while
others have GTG.
The hihg proportion of GTG start codons may be linked to the fact that
mycoabcterial genomes are G-C rich (typically 55-65%).
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Dr Koen A.L. De Smet
Department of Medical Microbiology
Imperial College Medical School at St Mary's
London W2 1PG
Tel: (+44)-(0)171-594 3946
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