which cyotkines as adjuvants for immunization of mice?
schnibbe at mpimg-berlin-dahlem.mpg.de
Wed Apr 22 16:04:47 EST 1998
imagine you want to administer a synthetic vaccine construct to Balb/c
mice. The construct shall confer protective immunity against a bacterial
pathogen (the bac is not an intracellular pathogen).
You now want to add cytokines as adjuvants.
My questions: Which cytokines would you use? What is the state of the
art in the confusing field of cytokine interaction/networking for this
Any references/citations for _this_ question? (I got all the _basic_
cytokine papers I would guess....)
My thoughts are to favor a Th2 response and to use IL-4 and GM-CSF.
Thank you very much in advance,
Max-Planck-Institut fuer Molekulare Genetik
Ihnestr. 73 14195 Berlin Germany
tel +49 (0)30-8413-1280
fax +49 (0)30-8413-1385
email schnibbe at mpimg-berlin-dahlem.mpg.de
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