Q Toxicological properties of Wortmannin (from Penicillium fumic

[Wolfgang Schechinger]

Hi all, 

I'm using wortmannin (dissolved in DMSO - is likely to penetrate 
gloves and skin) for inhibiting PI-3-kinase. IC50 is quite low (5nM), 
so 1 mg is lasting virtually forever. My stock solution is 1mM.

Has anybody out there knowledge to share about intoxication symptoms 
(the MSDS says nothing about this issue)? Are there long term 
effects?

BTW - I neither want to poison coffe makers, water dispensers, sugar 
boxes or lovers.

Wolfgang
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Wolfgang Schechinger         
University of Tuebingen, Germany
email: wgschech at med.uni-tuebingen.de * wwWait: http://www.medizin.uni-tuebingen.de/~wgschech/start.htm
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