inhibitors of DNA-binding proteins

Bernard P. Murray, PhD bpmurray*STUFFER* at socrates.ucsf.edu
Tue Aug 25 17:12:15 EST 1998


In article <6rv2ij$he5 at neuro.usc.edu>, william at neuro.usc.edu (William Sun)
wrote:

> Hello all,
> 
> Can anyone think of an example(s) where a small molecule (MW < 500) can 
> inhibit a DNA-binding protein (e.g. transcription factors)?

I'm sure question will generate a lot of interesting replies.
     Here's a couple of answers;
a) Short peptides comprising part of the transcription factor or
(if required) the coactivator
b) Maybe EDTA or another chelator?

Is your transcription factor ligand activated?  This would
open up possibilities for another group of molecules.
     Bernard
-- 
Bernard P. Murray, PhD
Dept. Cell. Mol. Pharmacol., UCSF, San Francisco, USA



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