inhibitors of DNA-binding proteins

Dom Spinella dspinella at chugaibio.com
Tue Aug 25 15:27:08 EST 1998


> Hello all,
> 
> Can anyone think of an example(s) where a small molecule (MW < 500) can 
> inhibit a DNA-binding protein (e.g. transcription factors)?
> 
> -- 
> William Sun, Ph.D               
> Metabasis Therapeutics, Inc.           Phone: (619) 622-3930
> 9390 Towne Centre Drive                FAX:   (619) 622-5545
> San Diego, CA 92121                    Email: william at alum.mit.edu 
> 


It seems to me that you'd have to count corticosteroids and synthetic
analogs like dexamethasone as molecules which fit this description, no?
--Dom Spinella



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