inhibitors of DNA-binding proteins

Wolfgang Schechinger wgschech at med.uni-tuebingen.de
Tue Aug 25 15:03:57 EST 1998


what about highly negative charged polysulfates and polyphosphates 
like low molecular sugar sulfates and phosphates,
(heparinoids), inositol hexasulfate, inositol hexaphosphate
or oligonucleotides (phosphorothiates and other mimics), peptide 
nucleic acids?

to start the debate

Wolfgang

> Hello all,
> 
> Can anyone think of an example(s) where a small molecule (MW < 500)
> can inhibit a DNA-binding protein (e.g. transcription factors)?
> 
> -- 
> William Sun, Ph.D               
> Metabasis Therapeutics, Inc.           Phone: (619) 622-3930
> 9390 Towne Centre Drive                FAX:   (619) 622-5545
> San Diego, CA 92121                    Email: william at alum.mit.edu 
> 
> 
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usual disclaimers apply * This message is RNAse free - please don't touch!
-----                              
Wolfgang Schechinger         
University of Tuebingen, Germany
email: wgschech at med.uni-tuebingen.de * wwWait: http://www.medizin.uni-tuebingen.de/~wgschech/start.htm
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