inhibitors of DNA-binding proteins

Chris Boyd chrisb at
Wed Aug 26 08:12:02 EST 1998

William Sun (william at wrote:

: Can anyone think of an example(s) where a small molecule (MW < 500) can 
: inhibit a DNA-binding protein (e.g. transcription factors)?

I suspect you're after naturally occurring inhibitors, so what follows
is probably irrelevant:

Our old friend ethidium bromide (MW ca. 400) is well known for its
ability to inhibit (e.g.) restriction enzymes.  Lots of intercalators
would also be predicted to share this property.  How about propidium

Best wishes,
Chris Boyd                      | from, but not \ MRC Human Genetics Unit,
Christopher.Boyd at  | on behalf of  /  Western General Hospital, \   Edinburgh, EH4 2XU, SCOTLAND

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