chaotropic: what's it mean?
svetlov at oncology.wisc.edu
Mon Aug 31 10:18:13 EST 1998
In article <mwcrepeau-2808981757410001 at curt.ucdavis.edu>,
mwcrepeau at ucdavis.edu (Marc Crepeau) wrote:
> What does this word mean? Nobody I've asked seems to know. I am
> referring to chaotropic as in the "chaotropic salts" which are used in
> Qiagen DNA purification kits.
Chaotropic is a term in protein chemistry referring to a solvent or solute
that has propensity (tropos) to induce disordered state (unfolded/thus
chaos) in proteins. Examples of such solutes are guanidinium chloride and
urea. A related term is cosmotropic - something with propensity to
induce/maintain ordered (folded/thus cosmos) state, examples or cosmotropic
solutes are ammonium sulfate and arginine.
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