cyanogen bromide cleavage

[JJ Miranda]

Jonathan Anderson (JAnderson at botany.uq.edu.au) wrote:
: Does anyone know if a realtively high (300mM) concentration of NaCl has 
: any effect on cyanogen bromide cleavage???

I think free alkalies react with CNBr to form alkali bromide and alkali 
cyanide.  i.e. You often dispose of excess CNBr by mixing with dilute 
NaOH.  I don't know if 300mM is enough, but it probably reduces the 
amount of CNBr reacting with protein so that there might not be enough 
(or any) left.

Sincere regards,
JJ Miranda