neomycin-G418 confusion

Wolfgang Schechinger Wolfgang.Schechinger at
Mon Nov 9 06:11:50 EST 1998

Hello Michael, hello all!

Sorry, I was wrong. Since G418 normally is only used in 
selcetion of transfected eucaryotic because of its high price, I 
generalized too much.


> Almost. G418 is effective against both Prokaryotes and Eukaryotes. It
> was originally found (I think at Schering-Plough) as a standard
> antibacterial anti-biotic. It was an exciting and wonderful new drug...
> until they got to animal studies and all their mice died. Then they
> found it works on both. 
> kanamycin and neomycin only work well in proks, and are interchangable
> for E.coli work (kanamycin is much cheaper). Other bacteria do better
> with one drug or the other. G418 is just too expensive to use for
> bacteria but it would work fine.
> __________________________________________________________
> Michael Benedik                                         
> Department of Biology and Biochemistry                      
> University of Houston                   Tel: 713-743-8377
> 3201 Cullen Boulevard, HSC 402          Fax: 713-743-8351
> Houston, TX 77204-5513              email: benedik at
> __________________________________________________________
usual disclaimers apply * This message is RNAse free - please don't touch!
Wolfgang Schechinger         
University of Tuebingen, Germany
email: wgschech at * wwWait:

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