3'-untranslated conservation common or not?

John Watson watsonaj at bms.com
Mon Oct 5 15:29:26 EST 1998

As I understand it:

UTR's between species homologs often show conservation.  UTR's of subtypes (of
a given receptor, kinase, whatever) within a single species do not. This lack
of conservation allows for EST clustering based on 3' UTR sequence.


Frauke Naumann wrote:

> >Dear Soenke,
> >
> >Yes, the 3'UTR is very commonly conserved.
> >This region is believed to be involved in the regulation of transcript
> >stability (=> steady state level of expression) and intracellular
> >transport / localization of the transcript, as well as polyadenylation
> >In some cases, it enhances translation, too.
> > ....
> >
> >Patrick F.H. Lai  < PFHLai at looksmart.com >
> >Graduate Student
> >University of Toronto
> >Toronto, Ontario, Canada
> >
> Dear Patrick and netters,
> Concerning the conservation of 3'UTRs, how do you know it's really common? I
> thought the differences of 3'UTRs is the basis of mapping EST clones (that
> are mainly 3' reads ) in hybrid cell lines? The gene I cloned has also a
> conserved 3'UTR and now I don't know what to think: normal or special and
> therefore an interesting feature?
> Thanks for any information,
> Frauke

John Watson
Bristol-Myers Squibb Co.
Neuroscience Drug Discovery, Dept 405
Wallingford, CT 06492

watsonaj at bms.com
"If you're not part of the solution, you're part of the precipitate."

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