kozak leading sequence

Geoffrey Kidd gkidd at aptagen.com
Thu Oct 15 18:06:02 EST 1998


The Kozak sequence is where the ribosome interacts just prior to the
start codon.  consensus sequence for higher eukaryotes is:
GCCACC(ATG).  The consensus for a poor Kozak sequence in higher
eukaryotes is:  CATTGG(ATG).  The consensus sequence for yeast is:
AAAAAA(ATG), and the consensus for a poor sequence in yeast is:
CGGTGT(ATG).  (From T. Laz, J. Clements, and F. Sherman in
"Translational Regulation of Gene Expression," Joseph Elan, Ed., p. 417,
Plenum Press, 1987).  Good luck!

Geoffrey Kidd, Ph.D.
Technical Services Manager
Aptagen, Inc.
(888) 367-4312



chenlinan at 263.NET wrote:

> hi,
>
> What is kozak sequence? What will combine with it?
>
> thanks
>
> chen linan






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