murphy_r at licre.ludwig.edu.au
Tue Oct 20 23:02:12 EST 1998
In article <70j9kg$ir4$1 at metro.ucc.usyd.edu.au>, "Shirlene Lim" <s.lim at pasteur.microbio.usyd.edu.au> wrote:
>I've read in many articles that antifungals are made up in dimethyl
>sulfoxide as opposed to water. Why is this?
Shirlene, it's probably because of limited solubility of the active
ingredients in water. We have similar problems with some peptides we're using
- very hdrophobic and soluble in DMSO but not water. DMSO is quite an
acceptable vehicle for drugs, especially topical ones as the DMSO rapidly
carries the drug into the skin.
Hope this helps,
Roger Murphy, Ph.D.
Biological Production Facility
Ludwig Institute for Cancer Research
Austin & Repatriation Medical Centre
Heidelberg, Vic. 3084
Email murphy_r at licre.ludwig.edu.au
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