Dimethyl sulfoxide

[Roger Murphy]

In article <70j9kg$ir4$1 at metro.ucc.usyd.edu.au>, "Shirlene Lim" <s.lim at pasteur.microbio.usyd.edu.au> wrote:
>I've read in many articles that antifungals are made up in dimethyl
>sulfoxide as opposed to water. Why is this?

Shirlene, it's probably because of limited solubility of the active 
ingredients in water.  We have similar problems with some peptides we're using 
- very hdrophobic and soluble in DMSO but not water.  DMSO is quite an 
acceptable vehicle for drugs, especially topical ones as the DMSO rapidly 
carries the drug into the skin.

Hope this helps,

Roger



Roger Murphy, Ph.D.
Biological Production Facility
Ludwig Institute for Cancer Research
Austin & Repatriation Medical Centre
Studley Road,
Heidelberg,  Vic. 3084
Australia.

Tel  61-3-94965463
Fax  61-3-94965436
Email murphy_r at licre.ludwig.edu.au