Alternatively spliced isoforms differing by one amino acid

Rich Dudley rdudley+ at pitt.edu
Mon Mar 1 09:24:01 EST 1999

alex dobrovic wrote:

> Crosier et al report two  isoforms of c-kit differing in the inclusion or
> exclusion of a single serine residue.
> Does any one know of any other examples of alternatively spliced isoforms
> differing by one amino acid?
> Crosier PS, Ricciardi ST, Hall LR, Vitas MR, Clark SC, Crosier KE
> Expression of isoforms of the human receptor tyrosine kinase c-kit in
> leukemic cell lines and acute myeloid leukemia. Blood 1993 82(4):1151-8
> Alexander Dobrovic, Ph.D.
> Chief Medical Scientist
> Department of Haematology-Oncology
> The Queen Elizabeth Hospital
> Woodville, SA 5011, Australia
> Tel 011 (or your countries' international code) 61-8-8222 7676
> Fax 011 (or your countries' international code) 61-8-8222 6046
> adobrovi at medicine.adelaide.edu.au

There is a neurotransmitter receptor where variants differ by one AA,
although it's not a splice variant, it's a downstream processing of the
mRNA.  I can't remember, but I think it's called the Q/R site, and it might
be an NMDA receptor.

Good luck!


--- --- --- -- -- -- --- --- ---
Richard J. Dudley (rdudley+ at pitt.edu)
Research Specialist V
Dept. of Cell Biology and Physiology
University of Pittsburgh
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