Multiple amino acid mutagenesis

Tyson tyson at canada.com
Thu Nov 11 19:40:35 EST 1999


...depends on the protein's structure and function!


Noam Harel <hareln at mail.med.upenn.edu> wrote in message
news:382A0D21.21FB48A5 at mail.med.upenn.edu...
| Hi,
|
| I plan to mutate a stretch of up to 18 contiguous amino acids in a
| 600-residue protein. What would have the least predicted effect on
| overall protein structure? mutating to all alanines, all glycines, a
| mixture of both, or just deleting that stretch?
|
| Any suggestions would be muchly appreciated...
|
| Noam Harel
| University of Pennsylvania






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