RNA stability

Nick Theodorakis nicholas_theodorakis at urmc.rochester.edu
Fri Nov 19 15:53:46 EST 1999


In article <3835ab0e.2286620 at news.joice.net>, jhwurmbach at gmx.de
(Jan-Henner Wurmbach) wrote:

[snip]

> Degraded Formamide is Formic Acid (German: Ameisensäure).
> Probably reduces RNA Solubility and in the long run degrades RNA.

Since formic acid was used in one of the base-modifying reactions in
the Maxam-Gilbert sequencing protocol, I would say that it has a good
chance of degrading RNA.

Nick



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