most common amino acid?
Bernard Murray, PhD
spam at 127.0.0.1
Fri Nov 19 21:38:14 EST 1999
In article <3835E08B.ECE43A14 at uiuc.edu>, "Andrea Beckel-Mitchener, PhD"
<amitch at uiuc.edu> wrote:
> Does anyone know which amino acid is found in the most abundance in
> proteins? A good guess might be leucine due to the fact that it is
> coded for by 6 codons in the genetic code, however, this would assume
> that a gene's sequence is completely random. Any other notions?
Do you mean;
a) The most abundant in the cell? (so dependent upon expression levels)
b) The most abundant in proteins?
If it is the latter I calculated the relative abundance in all
sequences in SwissProt release 36 (relative to W) as follows;
So Leucine does indeed top the table. You can see that many
assumptions have been made but at least you have real (??) numbers.
Bernard P. Murray, PhD
bpmurray at cgl . ucsf . edu
Department of Cellular & Molecular Pharmacology, UCSF
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