Drug-induced necrosis

Menoret menoret at home.com
Sun Nov 21 20:10:35 EST 1999


I think that Nick must be right. Necrosis is not a process. Azide,
adenovirus, anoxia and hyperthermia trigger apoptosis to some extend.
Complement might be the way to go.  

Antoine Menoret. 

Nick Theodorakis wrote:
> 

> 
> Ian, I think you've come to the crux of the problem here. Necrosis
> isn't a process, it just means something died, and it did it in boring
> way. I don't think anybody ever thought about it as a process until
> apoptosis became "popular," at which point people considered it as an
> "alternative" to death by apoptosis. I would be surprised if you can
> come up with a unifying set of criteria that says: "the features of
> necrotic cell death are, yada yada yada."
> 
> I also think part of the problem might be that when a cell is in
> trouble, it would probably at least _try_ to undergo apoptosis, but if
> it is too sick it might die before it has a chance to kill itself.
> 
> Having said that, let me try to think of some things that might work
> off the top of my head:
> 
> Complement? Or something else that might poke a hole in the membrane?
> 
> Does azide trigger apoptosis? If not, that might work.
> 
> Severe hyperthermia? Like maybe 45C or more?
> 
> Infection with a lytic virus like Adeno?
> 
> Nick
> 
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