most common amino acid?

Andrea Beckel-Mitchener, PhD amitch at uiuc.edu
Mon Nov 22 15:06:08 EST 1999


Thanks for the calculation!  What exactly is "SwissProt release 36" and
what is the logic behind normalizing everything to W?
Andrea

"Bernard Murray, PhD" wrote:

> In article <3835E08B.ECE43A14 at uiuc.edu>, "Andrea Beckel-Mitchener, PhD"
> <amitch at uiuc.edu> wrote:
>
> > Does anyone know which amino acid is found in the most abundance in
> > proteins?

> Do you mean;
> a) The most abundant in the cell? (so dependent upon expression levels)
> or
> b) The most abundant in proteins?
>
> If it is the latter I calculated the relative abundance in all
> sequences in SwissProt release 36 (relative to W) as follows;
> A  6.1
> C  1.3
> D  4.3
> E  5.1
> F  3.3
> G  5.5
> H  1.8
> I  4.7
> K  4.8
> L  7.6
> M  1.9
> N  3.6
> P  4.0
> Q  3.2
> R  4.1
> S  5.8
> T  4.6
> V  5.3
> W  1.0
> Y  2.6
>
>    So Leucine does indeed top the table.  You can see that many
> assumptions have been made but at least you have real (??) numbers.
>    Bernard
>
> --
> Bernard P. Murray, PhD
> bpmurray at cgl . ucsf . edu
> Department of Cellular & Molecular Pharmacology, UCSF





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