protease cleavage site program

Kresten kresten at
Tue Oct 26 08:56:44 EST 1999

In article <01683d2c.1f55781b at>,
  nibelung <mancusoNOmaSPAM at> wrote:
> does anyone know of a free web program that will predict
> protease cleavage sites of a protein? thanks

The following web-sites will list you proteolytic fragments of an
entered sequence:

They all have different features so check them all out. One thing that
they do have in common is that none of them can tell you whether a given
site is exposed for proteolytic cleavage. So unless your protein is
unfolded you could easily miss some (all) of the predicted fragments.


you can download the program WinPep which can also be used for
predicting proteolytic fragments. One advantage for this program is that
it allows you to enter own (new) protease cleavage sites.


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Kresten Lindorff Larsen, Dept. Yeast Genetics

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