Kinetic of RNA degradation

Michael L. Sullivan mlsulliv at
Thu Aug 3 10:30:46 EST 2000

I was at a biochemistry seminar some time ago where the presenter (who is
an RNA biochemist) said that the half life of RNA at pH 7 (I think at pH 7)
and room temperature was 7 years!  This seems really stable, but he pointed
out that the half life of DNA was 7000 years.  Sorry, I don't have a
reference for this.


>Can somebody help me : how fast is the degradation of a RNA (say from
>20-mer to 100-mer) versus temperature in a buffer that does not contain
>RNAse (but sometimes magnesium ions).
>Thanks for your help


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