Trp oxidation, what does it take?
wind at biobase.dk
Thu Aug 10 06:47:49 EST 2000
I'm currently working with a synthetic peptide that contains a disulfide and
a Trp residue. The people who made it have told me that they oxidized the
cysteines into a disulfide with either atmospheric airation at slightly
alkaline pH or with DMSO. My question is if this treatment will be oxidative
enough to damage the Trp as well, i.e make it an oxindolealanine ?
Any information will be much appreciated!
Troels Wind, Ph.D.
Laboratory of Cellular Protein Science
Department of Molecular and Structural Biology
University of Aarhus
Gustav Wieds Vej 10C
8000 Aarhus C
Phone: (+45) 8942 5079
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