ECV 304 Are these endothelial cells?

Hendrik vandenBerg h.van at qub.ac.uk
Wed Feb 16 07:05:42 EST 2000


Hi

We plan to set up in vitro assays to screen novel compounds for
anti-angiogenic activity. An immortal endothelial cell line would make
for a useful experimental model. Many investigators have utilised the
ECV 304 immortalised umbilical vein endothelial cell line, but the
European Collection of Animal Cell Cultures state that PCR
fingerprinting identifies this line as being identical to the T-24
bladder line.

Can anybody confirm this? Papers were still appearing last year using
this line in angiogenic studies. 

Are there any other immortalised endothelial cell lines out there?

Help appreciated

Hendrik




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