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gain of function mutagenesis, how to do?

Richard P. Grant rgrant at netscape.net
Wed Jan 19 10:09:39 EST 2000

In article <3885C81B.28540D0 at gmx.net>, Frederik Börnke 
<ricky_boernke at gmx.net> wrote:

> Actually, I did some deletion constructs. However, if I delete only
> small
> portions from either C or N terminus interaction is completely
> abolished.
> What does that tell me wiht respect to the isoform speceficity of inter
> action?

I don't know what it tells you about isoform specificity, but how did 
you determine what deletions to make?  Are you sure that your mutants 
are folded?


Richard P. Grant MA DPhil          
Structural Studies Group, MRC-LMB
Please reply to rpg 'at' mrc-lmb.cam.ac.uk

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