CNBr cleavage + iodoacetamide ?

Peter Cherepanov peter.cherepanov at
Mon Jul 17 11:35:38 EST 2000

Dear all,

does somebody know for sure:

if CNBr would cleave at Cysteines when the protein was treated with
iodoacetamide ?????

(logically, the reaction proceeds through a 5-member ring during cleavage
at Met. With alkylated Cys there would be a 4-member ring, which should not
favor this reaction. But on the other hand, I heard of a modification at
Cys that will make CNBr cleave at Cys+Met !!).

hope to get your advice,



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