peptide design

D.D. Morgan D.D.Morgan at ncl.ac.uk
Mon May 15 10:33:18 EST 2000


I want to use synthetic peptides to disrupt an in vitro interaction
between two proteins I am working on. I think the interaction is due to
two motifs on one of the proteins. Would I be able to ablate/prevent the
interaction by using excess quantities of peptide to the motifs ?

If so how long should the peptides be - the motif is 10-12 aa in the
protein - should I synthesize this plus 4-6 aa either side for good
measure.

Any help / suggestions appreciated

Dave Morgan

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* Dave Morgan             | **.           .***.   .***.           .***.   .** *
* Dept of Human Genetics  | | | *       * | | | * | | | *       * | | | * | | *
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* NE2 4AA                 |                                                   *
* Tel: 0191-222-5129      |         e-mail: D.D.Morgan at newcastle.ac.uk        *
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