Best machine for in situ PCR

Rick A. Bright rbright at
Thu Oct 19 07:57:00 EST 2000

Well, I was coming from "my" world where everything is R&D.  Demonstrated my
limited eyesight.

Thanks for correcting me.

"Dr. Duncan Clark" <Duncan at> wrote in message
news:EUyvg8B5Nr75EAkz at
> In article <8slu6c$625$1 at>, the eminent Rick A. Bright
> at Emory University wrote
> >The licensing status of the thermocycler has no relevance if you use
> >licensed reagents (which is almost impossible to avoid).
> Wrong. When you buy licensed PCR reagents you are buying a limited
> license to practice PCR only for research and development use and only
> then for use on authorised PCR machines.
> Full license disclaimer is.
> A license under U.S. Patents 4.683.202, 4.683.195 and 4.965.188 or their
> foreign counterparts, owned by Hoffmann-La Roche Inc. and F. Hoffmann-La
> Roche Ltd ("Roche"), has an up-front fee component and a running-royalty
> component. The purchase price of this product includes limited,
> nontransferable rights under the running-royalty component to use only
> this amount of the product to practice the Polymerase Chain Reaction
> ("PCR") and related processes described in said patents solely for the
> research and development activities of the purchaser when this product
> is used in conjunction with a thermal cycler whose use is covered by the
> up-front fee component. Rights to the up-front fee component must be
> obtained by the end user in order to have a complete license. These
> rights under the up-front fee component may be purchased from Perkin-
> Elmer or obtained by purchasing an Authorized Thermal Cycler. No right
> to perform or offer commercial services of any kind using PCR, including
> without limitation reporting the results of purchaser's activities for a
> fee or other commercial consideration, is hereby granted by implication
> or estoppel. Further information on purchasing licenses to practice the
> PCR Process may be obtained by contacting the Director of Licensing at
> The Perkin-Elmer Corporation, 850 Lincoln Center Drive, Foster City,
> California 94404 or at Roche Molecular Systems, Inc., 1145 Atlantic
> Avenue, Alameda, California 94501.
> Duncan
> --
> The problem with being on the cutting edge is that you occasionally get
> sliced from time to time....
> Duncan Clark
> GeneSys Ltd.
> Tel: +44(0)1252376288
> FAX: +44(0)8701640382

More information about the Methods mailing list