Targeting cancer

Emir Khatipov ekhatipo at NOSPAMmidway.uchicago.edu
Fri Sep 29 22:01:35 EST 2000


Hello,
Could someone summarize (or just give a short introduction into) current
status of targeting cancer therapeutics: are there any preferable tissue or,
most important, cancer specific targets that are being investigated now or
which ones have been studied and became classical and are routinely used in
practice. By targets I mostly mean proteins that are getting higher
expressed in cancer cells than in the normal tissue, so that therapeutics
could be delivered and selectively accumulated in cancer cells rather than
in normal ones. My particular interest is whether there is any relevance
available so far on using metabolic enzymes as potettial specific targets
for untitumor treatment.

I just was thinking that if a cancer tissue is growing faster than normal
tissue, it could be quite limited in nutrients like nitrogen, sulphur, etc.,
as well as oxygen (unless angeogenesis would not provide enough compensation
for the nutrient limitation).
Nutrient deprivation would trigger expression of enzymes or forms of enzymes
that have higher affinity for growth substrates, and those enzymes may
function as nice targets. Does it make sense?

Another relevant question is whether there is a noticeable difference in
metabolizm (carbon, nitrogen, phosphorus, etc.) in prostate cancer cells vs.
normal prostate cells.

Any guides and references would be highly appreciated.

Thanks.
Emir











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