SDS debate

Michael Witty mw132 at
Thu Aug 9 04:42:00 EST 2001

Dear All,
        there is a debate in my lab about the extent to which SDS
denatures protein.  I think that SDS sticks, but the gross shape of the
protein is not altered very much (the protein still looks like a ball of
wool).  My collegue thinks that the protein is dramatically unfolded and
looks like a linear object, or a ball of wool unrolled.  What do we think?
Regards, Mike.

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