Fw: Fw: SNPs

Deanne Bell dbell at qnis.net
Wed Jan 24 13:52:17 EST 2001


Dear Dr. Nick Leaves

Thanks so much for the brief description.  I have noticed these
polymorphisms before but I was not aware that they had their own acronym 
:-)

Deanne Bell

----------
> From: Dr N.I. Leaves <nleaves at hgmp.mrc.ac.uk>
> To: Deanne Bell <dbell at qnis.net>
> Subject: Re: Fw: SNPs
> Date: Wednesday, January 24, 2001 1:59 AM
> 
> Hi Deanne,
> 
> SNPs are single nucleotide polymorphisms. They are stable single base
pair
> polymorphisms that occur quite naturally in genomic DNA. They are
> inherited in a typical mendelian fashion. So at any random point of
> genomic DNA you might have a run of sequence with say a G at one specific
> point of one allele and say a T on the other allele. Otherwise the
> allelic sequences are identical. Dont get confused with the complimentary
> strands which will be C and A in this example as normal.
> 
> These polymorphism occur at a rate of probably >1 / every 1000bp but they
> cluster. Quite simply you dont get these polymorphisms as frequently in
> coding/control regions of genes where they might cause altered proteins
> but rather they occur more often intronically and intragenically. Having
> said that there are many, many papers describing SNPs within genes as the
> functional cause of genetic diseases or being a contributing factor in
> complex diseases.
> 
> Hope this helps
> 
> Best wishes
> 
> Nick Leaves
> 
> (end) 
> ************************************************** 
> Dr N I Leaves
> Mouse Sequencing
> MRC HGMP Resource Centre 
> Hinxton 
> Cambridge CB10 1SB 
> tel: 01223 494557 (office) or 01223 494541 (lab)
> email: nleaves at hgmp.mrc.ac.uk
> **************************************************
> 
> 


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