Ames test: Ethidium bromide

Nick Theodorakis nicholas_theodorakis at urmc.rochester.edu
Wed Jul 18 10:59:18 EST 2001


In <180720011533391900%dmicklem at cmgm.nospam.invalid>, David 
Micklem wrote:

[...]

>oh and for the person who mentioned caffeine:
>
><70/6000ug, which counts as non-mutagenic. Maybe things have 
changed
>since 1975.

IIRC, caffeine's effects were due to chromosome instability, (perhaps due 
to perturbing the timing of mitosis?), rather than by chemically modifying 
the DNA. If so, then it would not ne assayed as positive by the Ames test.

Nick

-- 
Nick Theodorakis
nicholas_theodorakis at urmc.rochester.edu

 




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