monensin, nigericin and lysosomal pH

Wolfgang Schechinger wolfsc at
Tue Mar 6 21:22:54 EST 2001

Hi all, 

I noticed that monensin and nigericin are used to control 
intracellular pH. 
since nigericin forms a a kind of proton channel and makes sense to 
me, I don't understand the way monensin is acting since it allows 
sodium ions to pass. 
Any clues?


Dr. Wolfgang Schechinger
Lab N233 (c/o Dr. Steve Roffler)
Institute of Biomedical Sciences
Academia Sinica
Yen-Chio Yuan Rd. Sec.2
Taipei 115
Taiwan R.O.C.
Tel +886-2-2798-9152
Fax +886-2-2782-9142
Mobile +886-925-136893
wolfsc at


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