monensin, nigericin and lysosomal pH

[Wolfgang Schechinger]

Hi all, 

I noticed that monensin and nigericin are used to control 
intracellular pH. 
since nigericin forms a a kind of proton channel and makes sense to 
me, I don't understand the way monensin is acting since it allows 
sodium ions to pass. 
Any clues?

Wolfgang

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Dr. Wolfgang Schechinger
Lab N233 (c/o Dr. Steve Roffler)
Institute of Biomedical Sciences
Academia Sinica
Yen-Chio Yuan Rd. Sec.2
Taipei 115
Taiwan R.O.C.
Tel +886-2-2798-9152
Fax +886-2-2782-9142
Mobile +886-925-136893
wolfsc at ibms.sinica.edu.tw
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