Researchers Find Enzyme Crucial to Preservation of

HHMI bionews at
Tue Sep 25 10:44:02 EST 2001

Research News from the Howard Hughes Medical Institute (HHMI) 

Researchers Find Enzyme Crucial to Preservation of Memories

Using a technique to eliminate the function of one enzyme in a 
restricted memory-related region in the brains of mice, researchers 
have shown that the enzyme is important in consolidating long-term 

According to the researchers, their experiments which showed 
that defects in a key biochemical signaling pathway were responsible 
for the animals’ inability to improve their long-term memory in a 
series of maze tests constitute a powerful approach to understanding 
molecules involved in learning and memory.

Research published in the September 21, 2001, issue of the journal Science.

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