why is pL{H,N,P}CX low copy

Wolfgang Schechinger wolfsc at ibms.sinica.edu.tw
Wed Apr 10 12:00:59 EST 2002


Dear gurus,

is there any reason why these retroviral vectors are made low copy? There 
shouldn't be any inherent toxicity, is there? 
What would happen if one replaces the replication origin with that of a high 
copy vector (like pCDNA3)?

Regards, Wo
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Dr. Wolfgang Schechinger
Institute of Biomedical Sciences
Academia Sinica, Taipei, Taiwan

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