glycosylated proteins in the cytosol?

Kyle Legate legatek at mcmail.cis.mcmaster.ca
Tue Jan 15 14:56:18 EST 2002


On 14 Jan 2002, Wolfgang Schechinger wrote:

> Hi all there,
>
> Is there any example of a protein first glycosylated in the ER/Golgi pathway
> and then exported to the cytosol?
>
Not that I know of. If a N-linked glycosylated protein is found in the
cytosol it's in the process of being degraded by the ERAD pathway.
Glycosylated proteins can be found in the cytosol, but they are O-linked
glycans and attachment of the sugar happens in the cytosol (see for
example E-cadherin).

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legatek at mcmaster.ca		Kyle Legate            legatek at hotmail.com

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