Post-transcriptional regulation, why?
Trond Erik Vee Aune
trondaun at chembio.REMOVETHISBEFOREREPLYING.ntnu.no
Tue Sep 10 07:57:36 EST 2002
Frank O. Fackelmayer wrote:
> Hi Trond,
> The more levels of regulation, the better.
> PTR makes much sense. Consider mutations in a promoter that will
> increase or decrease transcription efficiency. Or viral infection with
> very strong transcription. Or the development of eggs, where lots of
> mRNA is made and stored for later use in the embryo.
> In those (and many more) cases it will be beneficial for the cell to
> have means to regulate translation rather than transcription.
> Hope this helps,
Yes, I do understand that it would be advantageous in these cases. But
what about constituvely expressed E.coli proteins that the cell needs to
have at a constant level? Why would evolution design sub-optimal
translation efficiency of these? Why not just have a weak promotor and
let translation be optimal? It seems to be a waste of energy to make
mRNA which will be degraded before translated because of inefficient
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