Betain * how does it work ?

Sven Klages sven_klages at
Thu Mar 20 06:26:24 EST 2003

Hi Folks,

using Betaine in PCR or sequencing can dramatically
improve the results.

What's the mechanism behind this effect ?

There are some explanations about DMSO or other
additives, but it's hard to find *something* about
how betain works.

Pol stabilisation ? Some interaction with the DNA ? ...

Any ideas or explanations ?

Best regards


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