rational siRNA design

Chang Zhu czhu at changbioscience.com
Tue Apr 6 19:13:23 EST 2004


SVM RNAi 3.6 --- Software for rational siRNA design

For more information, please visit http://www.changbioscience.com/
Comments and suggestions welcome. Thanks.

1. Incorporates recent advances in rational siRNA 
   design.
2. Selects siRNA target sequences based on simple 
   rules.
3. Learns from past successes and failures for 
   better siRNA design. 
4. Automatically designs oligos for a variety of 
   technical platforms:
     synthetic siRNA    in vitro translated siRNA
     shRNA              vector-based siRNA
5. Tailors to user-specific systems.   
6. Eliminates unintended targets by "Blast" search
   transcribed genome sequences or predicted genes. 
7. Avoids targeting to Single Nucleotide 
   Polymorphism (SNP) sites. 
8. Generates scrambled controls.

Chang



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