Triton X-100

[diana_barbosa from sapo.pt]

Hello,

I'm having some trouble with the solubilization of proteins contained  
in a lipidic secretion we're studying (using 2DE).
To overcome this problem, I'm preparing a series of trials with  
different lysis buffers, prepared with detergents  
alternative/complementary to CHAPS.
One of the alternatives mentioned in the literature is Triton X-100,  
but in some papers it appears that this detergent doesn't help  
solubilize hydrophobic proteins but rather precipitates them, creating  
a 2 fractions (hydrophilic and hydrophobic proteins). Is this true or  
am I misinterpreting?

Any help will be very welcome.
Thank you,

Diana