Quinolone Resistance

John Cherwonogrodzky jcherwon at dres.dnd.ca
Tue Oct 31 16:04:46 EST 1995


Dear David Shadick:
     I saw your query, and it reminded me of a paper given by Dr. Don Woods at 
a local CSM meeting in Calgary a few years back. They were working with 
ciprofloxacin treatment of cystic fibrosis patients. Although some strains of 
Pseudomonas aeruginosa became ciprofloxacin resistant, once treatment was 
stopped there was a strong reversal for these strains to become 
ciprofloxacin sensitive. It seems that because the antibiotic deals with DNA 
gyrase, the bug isn't happy in being resistant as it has to 
compromise a lot in its DNA synthetic mechanism. Once the selective advantage 
of being ciprofloxacin resistant is remove, there is a selective advantage of 
normal sensitive strains over abnormal resistant strains.
     Hope this helps...John



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