exotoxins

Mark S. Strom strom at listeria.nwfsc.noaa.gov
Mon Sep 11 16:27:53 EST 1995


"j.a." <hbbio081 at huey.csun.edu> wrote:
>anyone with info on clostridium botulinium exotoxins... mechanisms?      
>thanks...
>
If you mean the neurotoxins, recent work has shown them to be zinc
metalloproteases that enter nerve cells and block neurotransmitter
release via zinc-dependent cleavage of proteins involved in neuroexocytosis.  
Here's a recent review:

Montecucco, C, and Schiavo, G. 1994. Mechanism of action of
tetanus and botulinum neurotoxins. Mol. Microbiol. 13:1-8.

There have been several additional articles since this review, expanding
on the specificity for each of the antigenically distinct botulinum
neurotoxins (look up the same authors).

Mark S. Strom, Ph.D.        Ph (206) 860-3379  Fax (206) 860-3394
URD, NWFSC/NMFS/NOAA        URL: http://research.nwfsc.noaa.gov/
2725 Montlake Blvd. E.      Email: strom at listeria.nwfsc.noaa.gov
Seattle, WA  98112-2097            mstrom at sci.nwfsc.noaa.gov

molecular biology protocols:                                
http://research.nwfsc.noaa.gov/protocols.html





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