Neutralizers for Antibiotics

Ron Gerth rgerth at uhl.uiowa.edu
Wed Sep 20 15:07:02 EST 1995


I have a bit of a challange coming up.  I am doing some specialty testing for
a person that is working with a topical gel that contains Gentamycin and
Promomycin and is going to want a Preservative Effectiveness test ran on it.
I have looked through several books in an attempt to find a neutralizer 
for these compounds.  I am also going to do some membrane filtration 
studies looking at bioburden and general sterility, nothing "regulated" 
yet but I am sure that is coming.  Can somebody help me with a 
neurtalizer approach to this?  I am going to try to get the gel into a 
suspension using saline and tween 80 and rinse it with Fluid D after 
filtering and think that that might work.  The obvious problem is that 
when I do an APE test on it I can't rinse out the active ingredients.

Thanks in advance,

-- 
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Ronald Gerth					The University of Iowa
Public Health Microbiologist			Hygienic Laboratory
Internet: rgerth at uhl.uiowa.edu
Phone: (319) 335 4500				Fax:       (319) 335 4555

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