Neutralizers for Antibiotics

ken_bromberg at ken_bromberg at
Tue Sep 19 21:54:16 EST 1995

In article <43ps96$93k at>, <rgerth at> writes:
> Path:!psinntp!psinntp!gatech!!newsfeed.internetmci.c
> From: rgerth at (Ron Gerth)
> Newsgroups: bionet.microbiology
> Subject: Neutralizers for Antibiotics
> Date: 20 Sep 1995 20:07:02 GMT
> Organization: University of Iowa, Iowa City, IA, USA
> Lines: 23
> Distribution: world
> Message-ID: <43ps96$93k at>
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> I have a bit of a challange coming up.  I am doing some specialty testing 
> a person that is working with a topical gel that contains Gentamycin and
> Promomycin and is going to want a Preservative Effectiveness test ran on it.
> I have looked through several books in an attempt to find a neutralizer 
> for these compounds.  I am also going to do some membrane filtration 
> studies looking at bioburden and general sterility, nothing "regulated" 
> yet but I am sure that is coming.  Can somebody help me with a 
> neurtalizer approach to this?  I am going to try to get the gel into a 
> suspension using saline and tween 80 and rinse it with Fluid D after 
> filtering and think that that might work.  The obvious problem is that 
> when I do an APE test on it I can't rinse out the active ingredients.
> Thanks in advance,
> -- 
> Ronald Gerth					The University of Iowa
> Public Health Microbiologist			Hygienic Laboratory
> Internet: rgerth at
> Phone: (319) 335 4500				Fax:       (319) 335 4555
Gentamicin not gentamycin.

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