Iron complex degradation

Jorge L. Galazzo jlg at alumnae.caltech.edu
Thu Apr 11 16:38:52 EST 1996


In article <4kiq4p$fa4 at mserv1.dl.ac.uk>,
Chris Capell  <chris at esb.ucp.pt> wrote:
>Dear all,
>
>	I'm presently working with obligatly respiratory bacteria isolated
>from marine fish (Shewanella putrefaciens and fluorescent Psedomonads),
>looking at their ability to produce iron binding compounds, and trying 
>to assess any competitive advantage that siderophore production may 
>have during growth of the bacteria on spoiling fish. 
>	My question to the group (which may be best suited to the
>biochemists out there) concerns the degradation of iron complexes, I have
>not found any literature about post-mortem changes in heam-complexes
>(autolytic) for any animal or fish; or anything relating to
>natural/microbial lactoferrin/transferrin/ferritin breakdown. Does anyone
>know of any such work, or have any contacts that may be able to help me? 
>
>Any replies would be gratefully received.
>
>Christopher Capell.				
>Escola Superior de Biotecnologia,
>Universidade Catolica Portuguesa,
>Porto, PORTUGAL.
>

There was a very interesting paper on Infection and Immunity, vol.64, p.518
by Meyer et al. (1996) regarding the role of pyoverdin, the main siderophore
in iron-gathering capacity produced by Pseudomonas aeruginosa. The authors
showed that pyoverdin competes with transferrin for iron and that it is an
essential element for in vivo iron gathering and virulence expression in P.
aeruginosa.

Jorge Galazzo
jlg at alumni.caltech.edu




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